Frontiers | The importance of pharmacokinetics and pharmacodynamics in antimicrobial drug
development and their influence on the success of agents developed to combat resistant …

… in vitro data in static or dynamic time–kill curve assays (TKCA) to predict efficacy and the …
of PK/PD principles to predict effective dosages of AMDs in veterinary medicine. Given this …

… to predict the probability of target attainment and treatment … regimens to maximize antibacterial
efficacy while minimizing … highlight the importance of in-vitro PK/PD analysis combined …

… as paradigm drugs to evaluate the predictive performance of … Following extrapolation of in
vivo pharmacokinetic-… of companion drugs to antibacterial activity of the combination therapy is …

… randomized controlled trials, in vitro, in vivo, and clinical data … with the antimicrobial effect
of the drug (pharmacodynamics) [… pharmacokinetics/pharmacodynamics and predict treatment …

… drug-drug interactions can be predicted from in vitro data through IVIVC and pharmacokinetic…
has a huge potential in antimicrobial drug development to shorten TB treatments [110]. It is …

… are essential for the efficacy and safety of drugs. This topic is … profiles suitable for determining
the antibacterial activity and … vitro models as indicative of the pharmacokinetic behavior of …

… as the in vitro concentration … to predict AUC 0–24 , and as such, this approach is beneficial
for those antimicrobials in which AUC 0–24 /MIC ratios are the major determinants for efficacy. …

… of an antibacterial drug with suitable pharmacokinetic properties … In summary, valid AST
results will help the veterinary practitioner to (i) select the potentially most effective antimicrobial …

… MIC under steady-state pharmacokinetic conditions]) that best predicts bacterial killing, short…
more on nonclinical data to predict successful clinical treatment regimens, often to combat …